Description

Amyloid B-Protein (1-40) Iowa Mutation, Amyloid B-Protein (1-40) D23N, Abeta (1-40) D23N CAS NO 374796-72-2 is a synthetic peptide variant of the amyloid-beta protein, featuring a specific aspartic acid to asparagine substitution at position 23 (D23N), known as the Iowa mutation. This mutation is critical for modeling and studying the pathogenesis of familial Alzheimer's disease and cerebral amyloid angiopathy (CAA). It is an essential research-grade biochemical for academic institutions, pharmaceutical R&D departments, and diagnostic developers focused on neurodegenerative disease mechanisms, drug discovery, and biomarker assay development.

Application

• Alzheimer's Disease Research: Used as a key reagent to study the aggregation kinetics, toxicity, and structural properties of mutant amyloid-beta peptides in vitro and in cellular models.
• Drug Discovery & Screening: Serves as a target substrate in high-throughput screening (HTS) assays to identify and validate potential therapeutic compounds that inhibit fibril formation or promote clearance.
• Biomarker & Diagnostic Development: Employed in the development and calibration of immunoassays (ELISA, Western Blot) and biosensors designed to detect specific amyloid-beta isoforms or aggregates in biological samples.
• Neuroscience & Pathogenesis Studies: Essential for investigating the molecular mechanisms linking the Iowa mutation to accelerated oligomerization and increased vascular deposition, a hallmark of CAA.
• Biophysical & Structural Analysis: Utilized in techniques such as nuclear magnetic resonance (NMR), circular dichroism (CD), and electron microscopy to elucidate the conformational changes and fibril morphology induced by the D23N mutation.
• Animal Model Studies: Applied in preclinical research to induce or study amyloid pathology in transgenic or infusion-based animal models of Alzheimer's disease.

Basic Information

Product Name	Amyloid B-Protein (1-40) Iowa Mutation
CAS No.	374796-72-2
Molecular Formula	C194H295N55O58S
Molecular Weight	4329.8 g/mol
Synonyms	Amyloid β-Protein (1-40) D23N; Aβ(1-40) D23N; Aβ40 Iowa Mutant; Amyloid β-Peptide (1-40) (Iowa Mutant); Amyloid-β (1-40) Iowa Mutation; Asp23Asn Aβ40; DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA (D23N); β-Amyloid (1-40), Iowa Mutant; Abeta40 D23N
EINECS	Contact for details

Quality Control

Our research-grade peptides are manufactured under stringent quality systems. Each batch of Amyloid B-Protein (1-40) Iowa Mutation undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results from HPLC for purity assessment, Mass Spectrometry (MS) for molecular weight confirmation, and Amino Acid Analysis (AAA) for composition verification.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive) and easily oxidized; it is recommended to store under an inert atmosphere after opening and to equilibrate to room temperature in a desiccator before use to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by AAA)
Solubility	Soluble in 1% NH₄OH or DMSO, then dilute in buffer
Endotoxin Level	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.