Description

Fmoc-(R)-3-Amino-3-(3-Nitro-Phenyl)-Propionic Acid is a high-purity, non-natural amino acid derivative featuring an Fmoc-protected amine group and a nitro-substituted aromatic side chain. This compound is essential for the solid-phase peptide synthesis (SPPS) of complex peptides and peptidomimetics, where it introduces a chiral center and a chemically modifiable aromatic nitro group. It is primarily used by research institutions and pharmaceutical companies engaged in drug discovery, particularly for developing therapeutic peptides and creating specialized chemical libraries. The product is supplied with a guaranteed Certificate of Analysis to ensure batch-to-batch consistency and synthesis reliability.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key chiral building block for the incorporation of a modified phenylalanine analog into peptide chains.
• Pharmaceutical Research & Drug Discovery: Used in the development of novel peptide-based therapeutics, enzyme inhibitors, and receptor ligands.
• Chemical Biology & Proteomics: Employed to synthesize peptide probes and affinity tags for studying protein-protein interactions and enzyme activity.
• Combinatorial Chemistry: A valuable component for generating diverse peptide libraries for high-throughput screening against biological targets.
• Material Science: Potential use in synthesizing specialized polymers and biomaterials with unique aromatic and chiral properties.

Basic Information

Item	Detail
Product Name	Fmoc-(R)-3-Amino-3-(3-Nitro-Phenyl)-Propionic Acid
CAS No.	374791-04-5
Molecular Formula	C24H20N2O6
Molecular Weight	432.43 g/mol
Synonyms	Fmoc-(R)-3-Amino-3-(3-nitrophenyl)propanoic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-3-(3-nitrophenyl)propionic Acid; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-nitrophenyl)propanoic Acid; Fmoc-3-Amino-3-(3-NO2-Ph)-Prop-OH (R-isomer); Fmoc-R-3-Amino-3-(3-Nitro-Phenyl)-Propionic Acid; Fmoc-R-3-Amino-3-(3-Nitrophenyl)propionic Acid; Fmoc-(R)-3-Amino-3-(m-nitrophenyl)propionic Acid
EINECS	Contact for details

Quality Control

Our Fmoc-(R)-3-Amino-3-(3-Nitro-Phenyl)-Propionic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure the material meets the stringent requirements for pharmaceutical research and peptide synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.