Description

Fmoc-L-3-Nitrophenylalanine CAS NO 374791-01-2 is a protected amino acid derivative featuring a nitro-substituted aromatic side chain, essential for solid-phase peptide synthesis (SPPS). This compound is a critical building block for introducing the unique 3-nitrophenylalanine residue into peptide sequences, enabling advanced research in medicinal chemistry and biochemistry. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions developing novel peptide-based therapeutics, diagnostic probes, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid for the automated synthesis of custom peptides containing the 3-nitrophenylalanine moiety.
• Medicinal Chemistry & Drug Discovery: Used to incorporate a nitro-aromatic group into peptide backbones for structure-activity relationship (SAR) studies and the development of enzyme inhibitors or receptor ligands.
• Bioconjugation & Probe Development: The nitro group serves as a versatile handle for further chemical reduction to an amine, facilitating site-specific labeling with fluorescent dyes, biotin, or other reporter molecules.
• Biochemical Research: Employed in studying protein-protein interactions, enzyme mechanisms, and as a component in peptide libraries for high-throughput screening.
• Material Science: Potential use in the synthesis of functionalized polymers or smart materials where nitro-aromatic peptides impart specific electronic or optical properties.

Basic Information

Product Name	Fmoc-L-3-Nitrophenylalanine
CAS No.	374791-01-2
Molecular Formula	C24H20N2O6
Molecular Weight	432.43 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-nitro-L-phenylalanine; Fmoc-3-Nitro-Phe-OH; Fmoc-L-Phe(3-NO2)-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-(3-nitrophenyl)propanoic acid; N-α-Fmoc-3-nitrophenylalanine; Fmoc-3-nitrophenylalanine; N-Fmoc-3-nitro-L-phenylalanine
EINECS	Contact for details

Quality Control

Our Fmoc-L-3-Nitrophenylalanine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	-10.0° to -15.0° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.