Description

L-Glutamic Acid, n-[4-[1-[(2,4-Diamino-6-Pteridinyl)Methyl]-3-Butyn-1-Yl]Benzoyl]-, 1,5-Dimethyl Ester is a sophisticated, high-purity chemical building block designed for advanced research and development. This compound is critical for pharmaceutical and biochemical applications where precise molecular structure and purity are paramount. It serves as a key intermediate for researchers in medicinal chemistry, particularly in the development of novel therapeutic agents and enzyme inhibitors targeting specific biological pathways.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of targeted drug candidates, particularly in oncology and metabolic disease research.
• Biochemical Research: Used in the study of enzyme mechanisms and as a precursor for labeled compounds in tracer studies.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Preclinical Development: Utilized in the synthesis of compounds for in vitro and in vivo biological testing.

Basic Information

Product Name	L-Glutamic Acid, n-[4-[1-[(2,4-Diamino-6-Pteridinyl)Methyl]-3-Butyn-1-Yl]Benzoyl]-, 1,5-Dimethyl Ester
CAS No.	374777-77-2
Molecular Formula	C27H28N6O6
Molecular Weight	532.55 g/mol
Synonyms	1,5-Dimethyl N-[4-[1-[(2,4-diaminopteridin-6-yl)methyl]but-3-yn-1-yl]benzoyl]-L-glutamate; L-Glutamic acid, N-[4-[1-[(2,4-diamino-6-pteridinyl)methyl]-3-butyn-1-yl]benzoyl]-, 1,5-dimethyl ester; Pteroic acid-glutamic acid conjugate derivative; Folate analog intermediate; Antifolate synthesis intermediate
EINECS	Contact for details

Quality Control

Our L-Glutamic Acid, n-[4-[1-[(2,4-Diamino-6-Pteridinyl)Methyl]-3-Butyn-1-Yl]Benzoyl]-, 1,5-Dimethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for research and development use. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccant or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.