Description

Ethyl 4-(4-Chlorophenyl)-6-Phenyl-2-Thioxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the tetrahydropyrimidine class of heterocyclic compounds. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs) and other fine chemicals. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing new therapeutic and crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, cardiovascular diseases, and anti-inflammatory applications.
• Agrochemical Research: Serves as a core scaffold for developing new-generation herbicides, fungicides, and insecticides with specific modes of action.
• Chemical Synthesis Building Block: Utilized in organic synthesis for constructing complex polycyclic frameworks and heterocyclic systems due to its reactive functional groups.
• Material Science Research: Investigated as a potential monomer or additive for creating specialized polymers with unique thermal or optical properties.
• Academic & R&D: Employed in university and corporate research laboratories for methodological studies and the discovery of new chemical entities.

Basic Information

Product Name	Ethyl 4-(4-Chlorophenyl)-6-Phenyl-2-Thioxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate
CAS No.	372975-55-8
Molecular Formula	C19H17ClN2O2S
Molecular Weight	372.87 g/mol
Synonyms	Ethyl 4-(4-chlorophenyl)-6-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate; 5-Carbethoxy-4-(4-chlorophenyl)-6-phenyl-3,4-dihydro-2(1H)-pyrimidinethione; 4-(4-Chlorophenyl)-6-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester; DHPM derivative; Biginelli reaction product; Tetrahydropyrimidine-5-carboxylate ester
EINECS	Contact for details

Quality Control

Our Ethyl 4-(4-Chlorophenyl)-6-Phenyl-2-Thioxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) that detail specifications including assay, impurity profiles, and residual solvents, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.