Description

[3-Iodo-4-(Trifluoromethyl)Phenyl]Methanol, 4-(Hydroxymethyl)-2-Iodobenzotrifluoride is a high-value, multi-functional aromatic building block featuring both a reactive hydroxymethyl group and a halogenated trifluoromethyl substituent. This compound matters for its role as a critical intermediate in the synthesis of complex molecules, particularly in pharmaceutical and agrochemical research where the introduction of fluorine and iodine atoms is strategically important for modulating bioactivity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the life sciences sector for creating novel active ingredients, as well as by manufacturers of advanced materials and liquid crystals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in oncology and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the trifluoromethyl group enhances lipophilicity and biological activity.
• Liquid Crystal Materials: Serves as a building block for fluorine-containing liquid crystal compounds used in display technologies.
• Organic Synthesis & Catalysis: Employed in cross-coupling reactions (e.g., Suzuki, Sonogashira) and as a precursor for ligands in catalytic systems.
• Material Science Research: Utilized in the synthesis of specialty polymers and advanced organic materials with unique electronic or surface properties.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development and quality control in chemical manufacturing.

Basic Information

Item	Detail
Product Name	[3-Iodo-4-(Trifluoromethyl)Phenyl]Methanol, 4-(Hydroxymethyl)-2-Iodobenzotrifluoride
CAS No.	372120-52-0
Molecular Formula	C8H6F3IO
Molecular Weight	302.04 g/mol
Synonyms	2-Iodo-α,α,α-trifluoro-p-tolylmethanol; 4-(Hydroxymethyl)-2-iodobenzotrifluoride; (3-Iodo-4-(trifluoromethyl)phenyl)methanol; 2-Iodo-4-(trifluoromethyl)benzyl alcohol; 3-Iodo-4-trifluoromethylbenzyl alcohol; α,α,α-Trifluoro-2-iodo-4-methylbenzenemethanol; 4-(Hydroxymethyl)-2-iodo-α,α,α-trifluorotoluene
EINECS	Contact for details

Quality Control

Our production of [3-Iodo-4-(Trifluoromethyl)Phenyl]Methanol adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and traceable to each lot. We support cGMP and ISO 9001 standards for pharmaceutical and industrial applications, ensuring reliable supply and product integrity for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.