Description

Benzyl 4-(4-Fluorophenyl)-6-Methyl-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound serves as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting cardiovascular and neurological pathways. It is essential for pharmaceutical R&D laboratories, process development chemists, and manufacturers engaged in the production of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of dihydropyrimidine (DHPM) and Biginelli reaction-derived drug candidates.
• API Synthesis: Used in the development and manufacturing of calcium channel blockers and other cardiovascular drugs.
• Medicinal Chemistry Research: A valuable scaffold for structure-activity relationship (SAR) studies and the creation of new chemical libraries for biological screening.
• Process Chemistry: Employed in route scouting, optimization, and scale-up activities for cost-effective API production.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP-compliant production runs.

Basic Information

Product Name	Benzyl 4-(4-Fluorophenyl)-6-Methyl-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate
CAS No.	367907-90-2
Molecular Formula	C19H17FN2O3
Molecular Weight	340.35 g/mol
Synonyms	Benzyl 4-(4-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate; 5-Carbomethoxy-4-(4-fluorophenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one benzyl ester; 4-(4-Fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic Acid Benzyl Ester; Biginelli Adduct Derivative; DHPM Ester; CAS 367907-90-2
EINECS	Contact for details

Quality Control

Our Benzyl 4-(4-Fluorophenyl)-6-Methyl-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate is manufactured under a strict quality management system. Each batch is subjected to rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development and production needs with material suitable for research use through to cGMP-grade manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.