Description

n-Boc-4-Amino-L-Phenylalanine-T-Butyl Ester CAS NO 367258-86-4 is a protected amino acid derivative, specifically a Boc-protected phenylalanine analog, serving as a critical chiral building block in organic synthesis. Its primary value lies in providing a versatile, orthogonally protected intermediate that enables the selective construction of complex peptides and peptidomimetics. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for developing active pharmaceutical ingredients (APIs), peptide-based therapeutics, and advanced chemical libraries.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate protected phenylalanine residues into peptide chains.
• Proteomics Research: Serves as a reagent in the study of protein structure, function, and peptide-protein interactions.
• Combinatorial Chemistry: A valuable scaffold for generating diverse chemical libraries in drug discovery and lead optimization.
• Bioconjugation: Employed in the preparation of peptide conjugates for diagnostic and therapeutic applications.
• Academic & R&D: Used in university and industrial research laboratories for methodological development in organic and medicinal chemistry.

Basic Information

Item	Details
Product Name	n-Boc-4-Amino-L-Phenylalanine-T-Butyl Ester
CAS No.	367258-86-4
Molecular Formula	C₁₈H₂₈N₂O₄
Molecular Weight	336.43 g/mol
Synonyms	Boc-4-Amino-L-Phe-OtBu; (S)-2-((tert-Butoxycarbonyl)amino)-3-(4-aminophenyl)propanoic acid tert-butyl ester; tert-Butyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-aminophenyl)propanoate; Boc-4-NH2-Phe-OtBu; N-α-Boc-4-amino-L-phenylalanine tert-butyl ester; 4-Amino-L-phenylalanine, N-Boc-, tert-butyl ester; Protected 4-Aminophenylalanine derivative
EINECS	Contact for details

Quality Control

Our n-Boc-4-Amino-L-Phenylalanine-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.