Description

Darexaban Maleate CAS NO 365462-24-4 is a high-purity, non-peptidic small molecule inhibitor of Factor Xa, a key enzyme in the blood coagulation cascade. This compound is of significant interest for pharmaceutical research and development, particularly in the field of anticoagulant therapy. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in cardiovascular drug discovery and preclinical studies.

Application

• Pharmaceutical Intermediate: Serves as a critical active pharmaceutical ingredient (API) or advanced intermediate in the synthesis of novel anticoagulant medications.
• Biochemical Research: Used as a selective tool compound in in vitro studies to investigate the role of Factor Xa in thrombosis and hemostasis pathways.
• Preclinical Development: Employed in animal model studies to evaluate the efficacy, pharmacokinetics, and safety profile of next-generation oral anticoagulants.
• Reference Standard: Acts as a high-purity analytical standard for quality control (QC) and method development in pharmaceutical analysis using HPLC or LC-MS.
• Mechanism of Action Studies: Facilitates research into structure-activity relationships (SAR) for designing improved Factor Xa inhibitors with better selectivity and potency.

Basic Information

Product Name	Darexaban Maleate
CAS No.	365462-24-4
Molecular Formula	C24H24ClN5O4 • C4H4O4
Molecular Weight	593.99 g/mol
Synonyms	Darexaban maleate salt; YM150 maleate; 1-(3-Carbamoyl-4-[(5-chloropyridin-2-yl)amino]phenyl)-3-[4-(N,N-dimethylcarbamoyl)benzyl]urea maleate; 1-[3-Aminocarbonyl-4-[(5-chloro-2-pyridinyl)amino]phenyl]-3-[[4-(dimethylaminocarbonyl)phenyl]methyl]urea (Z)-2-butenedioate; Factor Xa Inhibitor YM150 Maleate; UNII-6V6I6V3X5F
EINECS	Contact for details

Quality Control

Our Darexaban Maleate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, suitable for research and development applications. A Certificate of Analysis (COA) detailing results from HPLC, NMR, and other relevant tests is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.