Description

Ethyl 4-Chloro-6-Methoxyquinazoline-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the quinazoline class of heterocyclic compounds. This compound is a critical building block in the synthesis of targeted therapeutic agents, particularly kinase inhibitors used in oncology. It is essential for research institutions and pharmaceutical manufacturers engaged in the development of novel small-molecule drugs. The product is supplied with full traceability and a comprehensive Certificate of Analysis to ensure batch-to-batch consistency for your process development and scale-up needs.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of tyrosine kinase inhibitor (TKI) drug candidates for cancer treatment.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new quinazoline-based bioactive molecules.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a core scaffold in the manufacturing process of final active pharmaceutical ingredients targeting EGFR and other kinases.
• Chemical Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Process Chemistry: Utilized in route scouting and optimization for the efficient, scalable production of complex drug molecules.

Basic Information

Product Name	Ethyl 4-Chloro-6-Methoxyquinazoline-2-Carboxylate
CAS No.	364385-74-0
Molecular Formula	C₁₂H₁₁ClN₂O₃
Molecular Weight	266.68 g/mol
Synonyms	4-Chloro-6-methoxyquinazoline-2-carboxylic acid ethyl ester; Ethyl 4-chloro-6-methoxy-2-quinazolinecarboxylate; 2-Quinazolinecarboxylic acid, 4-chloro-6-methoxy-, ethyl ester; 364385-74-0; 4-Chloro-6-methoxyquinazoline-2-carboxylate ethyl ester; Ethyl (4-chloro-6-methoxyquinazolin-2-yl)carboxylate
EINECS	Contact for details

Quality Control

Our Ethyl 4-Chloro-6-Methoxyquinazoline-2-Carboxylate is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) documenting all test results is provided with each shipment to guarantee compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.