Description

8-Cyclopentyl-5-Methyl-2-(Methylthio)Pyrido[2,3-D]Pyrimidin-7(8H)-One is a high-purity, advanced pharmaceutical intermediate belonging to the pyridopyrimidinone class of heterocyclic compounds. This compound is of significant commercial interest for its role as a key building block in the synthesis of novel, potent kinase inhibitors and other biologically active molecules. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in oncology and targeted therapy drug discovery and development programs.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of targeted cancer therapeutics, particularly kinase inhibitors.
• Drug Discovery & Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs) targeting specific enzymatic pathways.
• Biochemical Research: Employed as a reference standard or a tool compound in biochemical assays to study enzyme inhibition and cellular signaling mechanisms.
• Contract Manufacturing: Supplied to CDMOs for scale-up synthesis under current Good Manufacturing Practice (cGMP) conditions for clinical trial material production.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis methodology and heterocyclic chemistry.

Basic Information

Product Name	8-Cyclopentyl-5-Methyl-2-(Methylthio)Pyrido[2,3-D]Pyrimidin-7(8H)-One
CAS No.	362656-23-3
Molecular Formula	C₁₅H₁₉N₃OS
Molecular Weight	289.40 g/mol
Synonyms	8-Cyclopentyl-5-methyl-2-(methylsulfanyl)-8H-pyrido[2,3-d]pyrimidin-7-one; 5-Methyl-2-(methylthio)-8-cyclopentylpyrido[2,3-d]pyrimidin-7(8H)-one; 8-Cyclopentyl-5-methyl-2-(methylthio)-7,8-dihydropyrido[2,3-d]pyrimidin-7-one; 362656-23-3; Pyrido[2,3-d]pyrimidin-7(8H)-one, 8-cyclopentyl-5-methyl-2-(methylthio)-; SCHEMBL2180621; BDBM50389395; AKOS005258209
EINECS	Contact for details

Quality Control

Every batch of 8-Cyclopentyl-5-Methyl-2-(Methylthio)Pyrido[2,3-D]Pyrimidin-7(8H)-One is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided with each shipment. We support development with custom purity grades and analytical method development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.