Description

n-(3-Chloro-4-Methylphenyl)-5,6,7,8-Tetrahydrobenzo[4,5]Thieno[2,3-D]Pyrimidin-4-Amine is a high-purity, advanced pharmaceutical intermediate belonging to the tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine class of heterocyclic compounds. This compound is of significant commercial interest for its role as a critical building block in the synthesis of novel, potent kinase inhibitors and other targeted therapeutic agents. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing next-generation treatments for oncology and inflammatory diseases.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel protein kinase inhibitors for oncology research.
• Drug Discovery & Development: Used as a core scaffold in medicinal chemistry for structure-activity relationship (SAR) studies.
• Biochemical Research: Serves as a reference standard or a tool compound in enzymatic assays and biological screening.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis to create complex molecules with potential therapeutic activity.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the cGMP production of active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for the study of heterocyclic chemistry and drug design principles.

Basic Information

Product Name	n-(3-Chloro-4-Methylphenyl)-5,6,7,8-Tetrahydrobenzo[4,5]Thieno[2,3-D]Pyrimidin-4-Amine
CAS No.	362509-09-9
Molecular Formula	C19H18ClN3S
Molecular Weight	355.88 g/mol
Synonyms	4-[(3-Chloro-4-methylphenyl)amino]-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine; 4-Amino-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine, N-(3-chloro-4-methylphenyl) derivative; 362509-09-9; BMS-599626 intermediate; BMS599626 intermediate; BMS 599626 intermediate; 4-(3-Chloro-4-methylphenylamino)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine
EINECS	Contact for details

Quality Control

Our n-(3-Chloro-4-Methylphenyl)-5,6,7,8-Tetrahydrobenzo[4,5]Thieno[2,3-D]Pyrimidin-4-Amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide comprehensive Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.