Description

4-(4-Fluorophenyl)-6-(Trifluoromethyl)Pyrimidine-2-Thiol is a high-value fluorinated pyrimidine derivative, a key synthetic intermediate prized for its unique chemical reactivity. This compound matters for its role in constructing complex molecular architectures, particularly in the development of advanced pharmaceuticals and agrochemicals. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for synthesizing novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the biological activity of the pyrimidine-thiol core.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of specialty polymers and advanced organic materials.
• Ligand Synthesis: Employed in organometallic chemistry for the preparation of novel ligands used in catalysis.
• Chemical Biology Probe: Utilized in medicinal chemistry and drug discovery programs for structure-activity relationship (SAR) studies.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	4-(4-Fluorophenyl)-6-(Trifluoromethyl)Pyrimidine-2-Thiol
CAS No.	359899-79-9
Molecular Formula	C11H6F4N2S
Molecular Weight	274.24 g/mol
Synonyms	4-(4-Fluorophenyl)-6-(trifluoromethyl)-2-pyrimidinethiol; 4-(4-Fluorophenyl)-6-(trifluoromethyl)-2-mercaptopyrimidine; 2-Mercapto-4-(4-fluorophenyl)-6-(trifluoromethyl)pyrimidine; 6-(Trifluoromethyl)-4-(4-fluorophenyl)pyrimidine-2-thiol; 359899-79-9; 4-(p-Fluorophenyl)-6-(trifluoromethyl)-2-pyrimidinethiol
EINECS	Contact for details

Quality Control

Our 4-(4-Fluorophenyl)-6-(Trifluoromethyl)Pyrimidine-2-Thiol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for advanced intermediates intended for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.