Description

Benzenemethanethiol, 3,5-Difluoro- (9Ci) is a specialized fluorinated aromatic thiol building block of significant interest in advanced organic synthesis. Its unique structure, featuring both a reactive thiol (-SH) group and fluorine substituents, makes it a valuable precursor for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated drug candidates, particularly in kinase inhibitor and CNS-active molecule research.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides where the fluorine atoms enhance bioavailability and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science: Incorporated into polymers and advanced materials to modify surface properties, adhesion, and chemical resistance.
• Chemical Biology Probes: Utilized in bioconjugation and probe synthesis due to the reactivity of the thiol group for site-specific labeling.
• Custom Synthesis and R&D: A critical reagent for contract research organizations (CROs) and academic laboratories exploring new synthetic methodologies.

Basic Information

Product Name	Benzenemethanethiol, 3,5-Difluoro- (9Ci)
CAS No.	358358-66-4
Molecular Formula	C7H6F2S
Molecular Weight	160.19 g/mol
Synonyms	(3,5-Difluorophenyl)methanethiol; 3,5-Difluorobenzyl mercaptan; α-Mercapto-3,5-difluorotoluene; 3,5-Difluoro-α-toluenethiol; 3,5-Difluorobenzylthiol; (3,5-Difluorophenyl)methylthiol; 1-(Mercaptomethyl)-3,5-difluorobenzene
EINECS	Contact for details

Quality Control

Every batch of Benzenemethanethiol, 3,5-Difluoro- (9Ci) is produced and analyzed under strict quality management protocols. We ensure compliance with relevant industry standards for fine chemicals and advanced intermediates. Comprehensive analytical testing, including GC, HPLC, and NMR, is performed to verify identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation. This compound is easily oxidized; prolonged exposure to air should be avoided. Keep the container in a cool, dry, and well-ventilated area, away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 97.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.