Description

4-Bromo-2,5-Difluorobenzaldehyde is a versatile and high-purity aromatic aldehyde building block, distinguished by its strategically placed bromine and fluorine substituents. This compound is essential for facilitating advanced cross-coupling reactions and introducing key functional groups into complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic cores.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the difluoro and bromo groups enhance biological activity and stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and organic synthesis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as OLEDs and semiconductors, where fluorinated compounds are critical.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Custom Chemical Synthesis: Provides a reactive aldehyde handle for further derivatization (e.g., reductive amination, condensation) in contract research and manufacturing.

Basic Information

Product Name	4-Bromo-2,5-Difluorobenzaldehyde
CAS No.	357405-75-5
Molecular Formula	C7H3BrF2O
Molecular Weight	221.00 g/mol
Synonyms	2,5-Difluoro-4-bromobenzaldehyde; 4-Bromo-2,5-difluorobenzenecarboxaldehyde; Benzaldehyde, 4-bromo-2,5-difluoro-; 357405-75-5
EINECS	Contact for details

Quality Control

Our 4-Bromo-2,5-Difluorobenzaldehyde is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Keep away from strong oxidizing agents, strong bases, and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.