Description

Fmoc-β-Homotrp(Boc)-Oh is a protected, non-natural amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring high-purity building blocks to incorporate β-homotryptophan analogs into complex peptide sequences. It is essential for the pharmaceutical, biotechnology, and academic research sectors focused on developing novel peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected building block for the automated synthesis of custom peptides containing β-homotryptophan residues.
• Pharmaceutical Research & Development: For the discovery and development of novel peptide drugs, including hormone analogs, enzyme inhibitors, and receptor agonists/antagonists.
• Structure-Activity Relationship (SAR) Studies: To investigate the impact of side-chain modification and homologation on peptide bioactivity, stability, and pharmacokinetics.
• Bioconjugation and Probe Development: Used in the synthesis of peptide-based fluorescent probes, affinity tags, and drug conjugates for diagnostic and therapeutic applications.
• Academic & Contract Research: A vital reagent for universities and CROs conducting fundamental research in peptide chemistry, medicinal chemistry, and chemical biology.

Basic Information

Product Name	Fmoc-β-Homotrp(Boc)-Oh
CAS No.	357271-55-7
Molecular Formula	C30H30N2O6
Molecular Weight	514.57 g/mol
Synonyms	Fmoc-β-homoTrp(Boc)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N'-(tert-butoxycarbonyl)-β-homotryptophan; (2R)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino-3-[2-[(tert-butoxycarbonyl)amino]ethyl]-1H-indole-1-propanoic acid; Fmoc-β-homotryptophan(Boc)-OH; Fmoc-Hot(Boc)-OH; Fmoc-β-Hot(Boc)-OH; Boc-β-homotryptophan-Fmoc; Nα-Fmoc-Nin-Boc-β-homotryptophan
EINECS	Contact for details

Quality Control

Our Fmoc-β-Homotrp(Boc)-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry best practices, and specifications can be aligned with customer-specific requirements for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.