Description

3,5-Difluoro-4-Iodobenzaldehyde is a versatile and highly functionalized aromatic aldehyde building block, distinguished by its unique halogen substitution pattern. This compound is critical for advanced organic synthesis, particularly in the development of complex molecules for pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the life sciences and material science sectors for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting kinase inhibition or other receptor-based therapies.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides, leveraging the fluorine and iodine atoms for bioactivity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for creating advanced organic electronic materials, including ligands for metal complexes used in displays.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex biaryl structures.
• Fluorinated Probe Development: Utilized in medicinal chemistry for the synthesis of 18F or 19F-labeled compounds used in Positron Emission Tomography (PET) imaging and NMR spectroscopy.
• Chemical Research & Development: Employed in academic and industrial labs for method development and exploring new chemical spaces in heterocyclic and fluorinated chemistry.

Basic Information

Product Name	3,5-Difluoro-4-Iodobenzaldehyde
CAS No.	357166-64-4
Molecular Formula	C7H3F2IO
Molecular Weight	267.90 g/mol
Synonyms	4-Iodo-3,5-difluorobenzaldehyde; 3,5-Difluoro-4-iodo-benzaldehyde; Benzaldehyde, 3,5-difluoro-4-iodo-; 4-Iodo-3,5-difluorobenzenecarboxaldehyde; 3,5-Difluoro-4-iodobenzaldehyde; 357166-64-4 (CAS); 3,5-Difluoro-4-iodo-benzenecarbaldehyde
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-4-Iodobenzaldehyde is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.