Description

4-(3,4-Difluorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxo-5-pyrimidinecarboxylic acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique difluorophenyl-substituted tetrahydropyrimidinecarboxylic acid structure. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within the fields of oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates.
• API Synthesis: Used in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs), leveraging its fluorine-substituted aromatic system.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity.
• Preclinical Development: Employed in the production of compounds for pharmacological profiling and toxicology studies.
• Chemical Biology Probes: Can be utilized to create tool compounds for investigating biological pathways and target validation.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs offering bespoke chemical synthesis services.

Basic Information

Product Name	4-(3,4-Difluorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxo-5-pyrimidinecarboxylic acid
CAS No.	356566-58-0
Molecular Formula	C12H10F2N2O3
Molecular Weight	268.22 g/mol
Synonyms	5-Pyrimidinecarboxylic acid, 4-(3,4-difluorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxo-; 4-(3,4-Difluorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxopyrimidine-5-carboxylic acid; 356566-58-0; Difluorophenyl tetrahydropyrimidinecarboxylic acid derivative
EINECS	Contact for details

Quality Control

Every batch of 4-(3,4-Difluorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxo-5-pyrimidinecarboxylic acid is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with stringent industry standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.