Description

(5R)-5-Hydroxy-L-Lysine Dihydrochloride Monohydrate >=99.0% (At) is a high-purity, non-proteinogenic amino acid derivative, specifically the (5R) diastereomer of hydroxylysine. This compound serves as a critical chiral building block and biochemical research tool, valued for its defined stereochemistry and high chemical purity. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and the synthesis of specialized peptides and collagen analogs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly those targeting collagen-related disorders or requiring hydroxylysine motifs.
• Biochemical Research: Used as a standard or substrate in enzymatic studies, metabolic pathway analysis, and investigations into post-translational modifications, especially collagen biosynthesis and lysyl hydroxylase activity.
• Proteomics & Peptide Synthesis: Incorporated into custom peptides to study structure-activity relationships, mimic collagen sequences, or create stabilized peptide constructs.
• Nutritional Science Research: Employed in metabolic tracer studies to understand lysine metabolism and hydroxylation processes in vivo.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in HPLC, LC-MS, or other chromatographic assays.

Basic Information

Product Name	(5R)-5-Hydroxy-L-Lysine Dihydrochloride Monohydrate
CAS No.	355118-29-5
Molecular Formula	C6H16Cl2N2O4
Molecular Weight	251.11 g/mol
Synonyms	(2S,5R)-2,6-Diamino-5-hydroxyhexanoic acid dihydrochloride monohydrate; Hyl dihydrochloride monohydrate; 5-Hydroxy-L-lysine dihydrochloride monohydrate; (5R)-Hyl·2HCl·H2O; L-Hydroxylysine dihydrochloride monohydrate (5R isomer); 5R-Hydroxylysine 2HCl hydrate; (5R)-5-Hydroxy-L-lysine 2HCl·H2O
EINECS	Contact for details

Quality Control

Every batch of (5R)-5-Hydroxy-L-Lysine Dihydrochloride Monohydrate is manufactured and tested under a strict quality management system. We guarantee a minimum purity of 99.0% (by HPLC), with comprehensive identity confirmation and impurity profiling. A detailed Certificate of Analysis (COA), including results for assay, chiral purity, water content, and residual solvents, is provided with each shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the original container tightly sealed in a dry environment to prevent absorption of moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 99.0%
Chiral Purity (HPLC)	≥ 99.5% (5R isomer)
Water Content (KF)	5.0% - 8.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Specific Rotation [α]D20	+14.0° to +18.0° (c=1 in H2O)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.