Description

3-Quinolinecarboxylic Acid, 7-(1,4-Diazabicyclo[3.2.1]Oct-4-Yl)-6-Fluoro-1-[(1R,2S)-2-Fluorocyclopropyl]-1,4-Dihydro-8-Methoxy-4-Oxo- is a high-purity, advanced pharmaceutical intermediate with a complex bicyclic structure. This compound is critical for the synthesis of novel antibacterial agents, particularly targeting DNA gyrase and topoisomerase IV enzymes. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of next-generation fluoroquinolone antibiotics and other therapeutic agents.

Application

• Key Intermediate for Antibacterial Agents: Serves as a crucial building block in the synthesis of novel fluoroquinolone-class antibiotics.
• Pharmaceutical R&D: Used in medicinal chemistry research for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry: Employed in scale-up and process development for new active pharmaceutical ingredients (APIs).
• Reference Standard: Utilized as a high-purity analytical standard for quality control and regulatory submissions.
• Biochemical Research: Applied in studies investigating bacterial enzyme inhibition mechanisms.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 7-(1,4-Diazabicyclo[3.2.1]Oct-4-Yl)-6-Fluoro-1-[(1R,2S)-2-Fluorocyclopropyl]-1,4-Dihydro-8-Methoxy-4-Oxo-
CAS No.	354812-31-0
Molecular Formula	C₂₁H₂₄F₂N₃O₄
Molecular Weight	420.43 g/mol
Synonyms	7-(1,4-Diazabicyclo[3.2.1]oct-4-yl)-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; (1R,2S)-1-(2-Fluorocyclopropyl)-7-(1,4-diazabicyclo[3.2.1]octan-4-yl)-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; WCK 771 Intermediate; Advanced Fluoroquinolone Intermediate; Antibacterial Intermediate 354812-31-0.
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral purity determination, and identification by spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical development. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.