Description

6-Chloro-5-Iodopyrimidin-4-Amine is a high-purity halogenated pyrimidine building block essential for advanced organic synthesis. This compound matters as a versatile intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential kinase inhibitors, antiviral agents, and other small molecule therapeutics.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and plant growth regulators.
• Chemical Biology & Proteomics: Serves as a precursor for affinity probes, enzyme inhibitors, and other tool compounds for target identification and validation.
• Material Science: Intermediate in the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The iodine and chlorine substituents make it an excellent substrate for sequential palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings.
• Nucleoside & Nucleotide Analog Synthesis: Used as a scaffold for creating modified nucleobases with potential biological activity.

Basic Information

Product Name	6-Chloro-5-Iodopyrimidin-4-Amine
CAS No.	353272-15-8
Molecular Formula	C4H3ClIN3
Molecular Weight	255.44 g/mol
Synonyms	4-Amino-6-chloro-5-iodopyrimidine; 5-Iodo-6-chloropyrimidin-4-amine; 6-Chloro-5-iodo-4-pyrimidinamine; 4-Pyrimidinamine, 6-chloro-5-iodo-; 353272-15-8; 6-Chloro-5-iodopyrimidin-4-ylamine; 5-Iodo-6-chloro-4-aminopyrimidine
EINECS	Contact for details

Quality Control

Our 6-Chloro-5-Iodopyrimidin-4-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are available for every lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.