Description

Fmoc-L-β-Homothreonine(Otbu) is a protected, non-proteinogenic amino acid derivative essential for advanced peptide synthesis. This high-purity building block is critical for researchers and manufacturers requiring precise control over peptide structure and function. It is primarily utilized in the development of novel therapeutic peptides, peptidomimetics, and biochemical research tools where the incorporation of a modified threonine side chain is necessary.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected building block for the automated synthesis of complex and modified peptide sequences.
• Pharmaceutical R&D: Used in the research and development of peptide-based drugs, including hormone analogs and enzyme inhibitors.
• Peptidomimetic Design: Enables the creation of metabolically stable peptide mimics by incorporating the β-homothreonine scaffold.
• Bioconjugation: Serves as a specialized linker or handle for attaching peptides to other molecules, surfaces, or reporter groups.
• Chemical Biology Probes: Integral for synthesizing labeled or tagged peptides used in studying protein-protein interactions and cellular pathways.
• Academic & Institutional Research: Supports fundamental studies in organic chemistry, biochemistry, and medicinal chemistry.

Basic Information

Product Name	Fmoc-L-β-Homothreonine(Otbu)
CAS No.	353245-99-5
Molecular Formula	C24H29NO6
Molecular Weight	427.49 g/mol
Synonyms	Fmoc-β-homo-Thr(OtBu)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-[(2-methyl-2-propanyl)oxy]-L-homoalaninate; Fmoc-L-β-homothreonine(O-tert-butyl); (2S)-3-[(2-Methylpropan-2-yl)oxy]-2-(9H-fluoren-9-ylmethoxycarbonylamino)butanoic acid; N-α-Fmoc-L-β-homothreonine tert-butyl ether; Fmoc-Homothreonine(OtBu)-OH; Fmoc-β-hThr(OtBu)-OH; tert-Butyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-β-homothreoninate
EINECS	Contact for details

Quality Control

Our Fmoc-L-β-Homothreonine(Otbu) is manufactured under strict quality systems to ensure the high purity and consistency required for sensitive synthetic applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to confirm enantiomeric integrity. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.