Description

Fmoc-D-2,4-Dichlorophenylalanine CAS NO 352351-61-2 is a high-purity, non-natural amino acid derivative specifically engineered for advanced peptide synthesis. This compound is critical for introducing the unique steric and electronic properties of the D-2,4-dichlorophenylalanine side chain into peptide chains under Fmoc solid-phase protocols. It is an essential building block for research and development in pharmaceutical discovery, particularly for creating novel peptide-based therapeutics, diagnostics, and biochemical probes targeting complex biological pathways.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc-strategy, enabling the controlled assembly of complex peptides.
• Pharmaceutical Research: Used in the discovery and development of novel peptide drugs, including antimicrobial peptides (AMPs), hormone analogs, and targeted therapeutics.
• Peptidomimetics & Conformation Studies: Incorporation of the D-isomer and halogenated aromatic ring aids in studying peptide stability, bioavailability, and receptor interaction.
• Bioconjugation & Probe Development: Serves as a precursor for creating fluorescently labeled or affinity-tagged peptides for diagnostic and imaging applications.
• Combinatorial Chemistry Libraries: Used to generate diverse peptide libraries for high-throughput screening against biological targets.
• Academic & Institutional Research: Fundamental research tool in biochemistry, medicinal chemistry, and chemical biology departments.

Basic Information

Product Name	Fmoc-D-2,4-Dichlorophenylalanine
CAS No.	352351-61-2
Molecular Formula	C24H19Cl2NO4
Molecular Weight	456.32 g/mol
Synonyms	Fmoc-D-2,4-Dichloro-Phe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-2,4-dichlorophenylalanine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2,4-dichlorophenyl)propanoic acid; Fmoc-D-2,4-Cl2-Phe-OH; Fmoc-D-(2,4-DiCl)Phe; N-Fmoc-D-2,4-dichlorophenylalanine; Fmoc-2,4-dichloro-D-phenylalanine
EINECS	Contact for details

Quality Control

Our Fmoc-D-2,4-Dichlorophenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric excess, and identity confirmation via NMR and mass spectrometry. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research and cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere or with desiccant after each use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (D-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.