Description

7-Chloro-2-(methylthio)pyrido[2,3-d]pyrimidine is a high-purity, heterocyclic organic compound that serves as a critical advanced pharmaceutical intermediate. This compound matters for its role as a versatile building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in kinase inhibitor research and development. Pharmaceutical manufacturers and R&D organizations need this precise chemical scaffold to develop new therapeutic agents targeting various diseases.

Application

• Key intermediate in the synthesis of protein kinase inhibitors for oncology and inflammatory disease research.
• Building block for the development of Janus kinase (JAK) inhibitors and other targeted small-molecule therapies.
• Precursor in medicinal chemistry for creating novel pyridopyrimidine-based compounds with potential biological activity.
• Used in pharmaceutical R&D laboratories for process development and scale-up studies.
• Reference standard for analytical method development and quality control in API manufacturing.
• Starting material for custom synthesis services catering to the biotech and pharmaceutical industries.

Basic Information

Product Name	7-Chloro-2-(methylthio)pyrido[2,3-d]pyrimidine
CAS No.	352328-41-7
Molecular Formula	C8H6ClN3S
Molecular Weight	211.67 g/mol
Synonyms	7-Chloro-2-methylsulfanylpyrido[2,3-d]pyrimidine; 2-(Methylthio)-7-chloropyrido[2,3-d]pyrimidine; 7-Chloro-2-(methylmercapto)pyrido[2,3-d]pyrimidine; Pyrido[2,3-d]pyrimidine, 7-chloro-2-(methylthio)-; 352328-41-7; 7-Chloro-2-methylthiopyrido[2,3-d]pyrimidine
EINECS	Contact for details

Quality Control

Our 7-Chloro-2-(methylthio)pyrido[2,3-d]pyrimidine is manufactured under a strict quality management system to ensure batch-to-batch consistency and high purity suitable for pharmaceutical applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to ICH guidelines for stability and impurity characterization, providing the documentation required for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.