Description

(Nle6)-Sarafotoxin C CAS NO 352283-69-3 is a synthetic, site-specifically modified analog of the potent vasoconstrictor peptide, Sarafotoxin C. This engineered compound is crucial for advanced biochemical and pharmacological research, offering a stable tool to study endothelin receptor signaling pathways and cardiovascular physiology. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in cardiovascular drug discovery and receptor-ligand interaction studies.

Application

• Biochemical Research: As a high-purity reference standard for studying endothelin receptor (ETA and ETB) binding affinity and selectivity.
• Pharmacological Studies: Investigation of vasoconstriction mechanisms, vascular smooth muscle cell activity, and cardiovascular disease models.
• Drug Discovery & Development: A key intermediate or tool compound in the screening and development of novel endothelin receptor antagonists for treating hypertension and pulmonary arterial hypertension.
• Cell Signaling Pathways: Used to elucidate the role of endothelin systems in cellular proliferation, fibrosis, and other pathophysiological processes.
• Academic Research: Fundamental research in universities and institutes focusing on peptide chemistry, receptor biology, and cardiovascular science.

Basic Information

Product Name	(Nle6)-Sarafotoxin C
CAS No.	352283-69-3
Molecular Formula	C115H174N30O32S4
Molecular Weight	~2545.1 g/mol
Synonyms	Sarafotoxin S6c analog (Nle6); Norleucine6-Sarafotoxin C; [Nle6]-Sarafotoxin C; SRTX-C (Nle6); Endothelin-like peptide analog; ET-1/Sarafotoxin analog; Synthetic Sarafotoxin derivative; Research peptide 352283-69-3
EINECS	Contact for details

Quality Control

Our (Nle6)-Sarafotoxin C is manufactured under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 quality management principles, and our processes are designed to meet the rigorous demands of pharmaceutical and life science research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.