Description

(Thr46)-Osteocalcin (45-49) (Human) is a specific, phosphorylated pentapeptide fragment derived from the human osteocalcin protein. This compound is a critical research-grade biochemical tool used to study bone metabolism, vitamin K-dependent carboxylation, and intracellular signaling pathways. It is essential for researchers and developers in the fields of endocrinology, bone biology, and metabolic disease research, providing a precise molecular probe for investigating osteocalcin's undercarboxylated forms and their physiological roles.

Application

• Biomedical Research: Used as a reference standard and antigen in studies focusing on bone turnover, osteoblast activity, and the role of undercarboxylated osteocalcin.
• Assay Development: Critical for the calibration and validation of immunoassays (ELISA, RIA) designed to detect specific osteocalcin fragments in biological samples.
• Metabolic Studies: Employed in research investigating the endocrine functions of osteocalcin, particularly its effects on glucose metabolism and energy expenditure.
• Pharmaceutical R&D: Serves as a key reagent in drug discovery programs targeting bone-related disorders such as osteoporosis and metabolic bone diseases.
• Cell Signaling Research: Utilized to explore receptor-ligand interactions and downstream signaling cascades initiated by osteocalcin peptides.
• Quality Control: Acts as a purity standard for manufacturers producing diagnostic kits or related biochemical reagents.

Basic Information

Product Name	(Thr46)-Osteocalcin (45-49) (Human)
CAS No.	352279-02-8
Molecular Formula	C27H47N9O12
Molecular Weight	665.7 g/mol
Synonyms	Human Osteocalcin (45-49), Thr46-phosphorylated Osteocalcin fragment; OCN (45-49); Bone Gla Protein Fragment (45-49); Undercarboxylated Osteocalcin Peptide; hOC(45-49); pThr46-OC(45-49); Pentapeptide Tyr-Leu-Asp-pThr-Asp
EINECS	Contact for details

Quality Control

Every batch of (Thr46)-Osteocalcin (45-49) (Human) is manufactured and analyzed under strict quality protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing, including HPLC, MS, and amino acid analysis, to ensure compliance with research-grade standards. Comprehensive Certificates of Analysis (COA) detailing purity, chromatographic data, and analytical results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.