Description

5-Ethyl-6-Methyl-2-[(4-Methylquinazolin-2-Yl)Amino]Pyrimidin-4-Ol CAS NO 351423-92-2 is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of significant commercial value for its role in the research and development of novel therapeutic agents, particularly in oncology and other targeted disease areas. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic research institutions engaged in medicinal chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel small-molecule drug candidates, particularly kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes in drug discovery.
• Biochemical Reagent: Acts as a reference standard or a tool compound for biological target validation and assay development.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis for creating complex molecular architectures with specific pharmacological profiles.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for the production of clinical trial materials and non-commercial scale APIs.

Basic Information

Product Name	5-Ethyl-6-Methyl-2-[(4-Methylquinazolin-2-Yl)Amino]Pyrimidin-4-Ol
CAS No.	351423-92-2
Molecular Formula	C₁₆H₁₇N₅O
Molecular Weight	295.34 g/mol
Synonyms	2-[(4-Methyl-2-quinazolinyl)amino]-5-ethyl-6-methyl-4(3H)-pyrimidinone; 5-Ethyl-6-methyl-2-[(4-methylquinazolin-2-yl)amino]pyrimidin-4-ol; 4(3H)-Pyrimidinone, 2-[(4-methyl-2-quinazolinyl)amino]-5-ethyl-6-methyl-; CAS 351423-92-2; 2-((4-Methylquinazolin-2-yl)amino)-5-ethyl-6-methylpyrimidin-4-ol; 5-Ethyl-6-methyl-2-((4-methylquinazolin-2-yl)amino)pyrimidin-4(3H)-one
EINECS	Contact for details

Quality Control

Our 5-Ethyl-6-Methyl-2-[(4-Methylquinazolin-2-Yl)Amino]Pyrimidin-4-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption and potential degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.