Description

(R)-2-Amino-2-Carboxyethylmethanethiosulfonate is a high-purity chiral building block and biochemical reagent of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel pharmaceuticals and bioactive molecules, particularly those targeting neurological pathways and metabolic disorders. It is primarily needed by research institutions and pharmaceutical companies engaged in peptide mimetics, drug discovery, and the synthesis of complex, sulfur-containing active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new therapeutic agents, including enzyme inhibitors and receptor modulators.
• Peptide Chemistry: Used in the synthesis of modified peptides and peptidomimetics where the introduction of a protected thiol or disulfide linkage is required.
• Bioconjugation & Probe Development: Serves as a versatile reagent for site-specific protein labeling and the creation of biochemical probes due to its reactive methanethiosulfonate group.
• Asymmetric Synthesis: Employed as a building block in stereoselective reactions to construct molecules with defined (R)-configuration at the α-carbon center.
• Protecting Group Strategy: The methanethiosulfonate moiety can act as a protective group for thiols in multi-step synthetic sequences.
• Chemical Biology Research: Utilized in studies investigating protein structure-function relationships and redox biology.

Basic Information

Product Name	(R)-2-Amino-2-Carboxyethylmethanethiosulfonate
CAS No.	351422-29-2
Molecular Formula	C5H11NO5S2
Molecular Weight	229.27 g/mol
Synonyms	(R)-S-Methyl methanethiosulfonate-L-cysteine; (R)-2-Amino-3-[(methylsulfonyl)thio]propanoic acid; (R)-Amino carboxyethyl methanethiosulfonate; L-Cysteine S-methyl thiosulfonate (R-enantiomer); (2R)-2-Amino-3-[(methylsulfonyl)sulfanyl]propanoic acid; (R)-AMTS; (R)-MTSEA precursor
EINECS	Contact for details

Quality Control

Our (R)-2-Amino-2-Carboxyethylmethanethiosulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment and handled under conditions that minimize exposure to ambient light and humidity to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.