Description

Fmoc-Tyr(2-Cltrt)-Oh CAS NO 350241-80-4 is a protected tyrosine derivative, specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring high-purity, orthogonally protected amino acid building blocks to construct complex peptides with precision. It is an essential raw material for pharmaceutical R&D, biotechnology, and academic laboratories focused on developing novel peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid building block for the Fmoc/tBu strategy, enabling the controlled assembly of peptide chains.
• Pharmaceutical Research & Development: Used in the synthesis of peptide drug candidates, including hormones, enzyme inhibitors, and targeted therapeutics.
• Bioconjugation and Probe Development: Facilitates the site-specific introduction of tyrosine residues for subsequent labeling or cross-linking in antibody-drug conjugates (ADCs) or imaging probes.
• Combinatorial Chemistry: Serves as a versatile monomer in libraries for high-throughput screening to discover new bioactive peptides.
• Academic & Institutional Research: Essential for fundamental studies in biochemistry, structural biology, and medicinal chemistry involving peptide structure-activity relationships.
• Custom Peptide Service Providers: A fundamental reagent for CROs and CDMOs offering bespoke peptide synthesis services to the biopharma industry.

Basic Information

Product Name	Fmoc-Tyr(2-Cltrt)-Oh
CAS No.	350241-80-4
Molecular Formula	C45H36ClNO5
Molecular Weight	706.22 g/mol
Synonyms	Fmoc-Tyr(2-ClTrt)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-[bis(4-chlorophenyl)phenylmethyl]-L-tyrosine; Fmoc-O-(2-Chlorotrityl)-L-tyrosine; Fmoc-L-Tyrosine(2-ClTrt)-OH; Fmoc-Tyr(2-Cl-Trt)-OH; N-α-Fmoc-O-(2-chlorotrityl)-L-tyrosine; L-Tyrosine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-[bis(4-chlorophenyl)phenylmethyl]-
EINECS	Contact for details

Quality Control

Our Fmoc-Tyr(2-Cltrt)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the high standards required for sensitive peptide synthesis applications. Certificates of Analysis (COA) detailing purity, chiral purity, and residual solvent levels are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and performance.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.