Description

H-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Sta-Val-Ala-Glu-Phe-Oh CAS NO 350228-37-4 is a synthetic peptide sequence containing the statine (Sta) residue, a key structural motif known for its potent inhibitory activity against aspartic proteases. This compound is of significant value in pharmaceutical research and development, particularly for designing novel enzyme inhibitors. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of therapeutic agents for conditions such as hypertension, viral infections, and certain cancers, where protease inhibition is a validated therapeutic strategy.

Application

• Protease Inhibitor Research: Serves as a critical lead compound or reference standard in the study of renin, HIV-1 protease, and other aspartic proteases.
• Cardiovascular Drug Development: Used in the design and screening of novel antihypertensive agents targeting the renin-angiotensin system.
• Antiviral Agent Discovery: Applied in research programs focused on developing inhibitors for viral proteases, including those of HIV and hepatitis C virus.
• Biochemical Assay Development: Employed as a standard or substrate analog in enzymatic assays to study inhibition kinetics and mechanism of action.
• Peptide Chemistry & Structure-Activity Relationship (SAR) Studies: Utilized as a core scaffold for chemical modification to optimize potency, selectivity, and pharmacokinetic properties.
• Academic & Institutional Research: Supports fundamental research in enzymology, medicinal chemistry, and molecular biology.

Basic Information

Product Name	H-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Sta-Val-Ala-Glu-Phe-Oh
CAS No.	350228-37-4
Molecular Formula	C73H115N15O24
Molecular Weight	1570.8 g/mol
Synonyms	Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Sta-Val-Ala-Glu-Phe; KTE EIS EVN Sta VAE F; Peptide with Statine; Aspartic Protease Inhibitor Peptide; Renin Inhibitor Peptide Fragment; HIV Protease Inhibitor Analog; (3S,4S)-4-Amino-3-hydroxy-6-methylheptanoic acid containing peptide
EINECS	Contact for details

Quality Control

Our peptide products are manufactured under strict quality management systems. Each batch of H-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Sta-Val-Ala-Glu-Phe-Oh undergoes rigorous analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing purity, content, and analytical data are provided to ensure compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Content)	≥ 80%
Amino Acid Composition	Conforms to theoretical values
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.