Description

2-(Methylthio)Pyrimidine-5-Boronic Acid is a high-value boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its primary importance lies in enabling efficient carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone of pharmaceutical and advanced materials research. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who are developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for constructing pyrimidine-based scaffolds in drug discovery programs, particularly for kinase inhibitors and antiviral agents.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators containing functionalized pyrimidine rings.
• Material Science: Serves as a monomer or functionalization agent in the synthesis of organic electronic materials, such as those for OLEDs or conductive polymers.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura couplings to introduce the 2-(methylthio)pyrimidin-5-yl moiety into complex molecular architectures.
• Chemical Biology & Proteomics: Can be utilized in the development of chemical probes and affinity ligands for target identification and protein studies.
• Ligand Synthesis: Acts as a precursor for creating specialized bidentate or tridentate ligands used in catalysis.

Basic Information

Product Name	2-(Methylthio)Pyrimidine-5-Boronic Acid
CAS No.	348098-29-3
Molecular Formula	C5H7BN2O2S
Molecular Weight	169.99 g/mol
Synonyms	5-(Methylsulfanyl)pyrimidine-2-boronic acid; (5-(Methylthio)pyrimidin-2-yl)boronic acid; 2-(Methylthio)-5-pyrimidineboronic acid; 2-(Methylsulfanyl)pyrimidine-5-boronic acid; 2-Methylthiopyrimidine-5-boronic acid; 2-Pyrimidineboronic acid, 5-(methylthio)-; B-[5-(Methylthio)-2-pyrimidinyl]boronic acid
EINECS	Contact for details

Quality Control

Our 2-(Methylthio)Pyrimidine-5-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) for long-term storage and to prevent degradation upon repeated opening.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.