Description

5-Pyrimidinecarboxamide,4-(2-Fluorophenyl)-1,2,3,4-Tetrahydro-6-Methyl-2-Oxo-(9Ci) is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound matters for its critical role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular design. Pharmaceutical R&D laboratories and fine chemical manufacturers need this precise intermediate to develop next-generation drug candidates, leveraging its specific fluorinated pyrimidine scaffold for enhanced bioactivity and metabolic stability.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of proprietary drug molecules, especially in oncology and central nervous system (CNS) therapeutic research.
• Active Pharmaceutical Ingredient (API) Development: Used as a core structural motif for developing new APIs that target specific enzymes or receptors.
• Biochemical Research: Employed in academic and industrial research settings as a reference standard or probe molecule for studying biological pathways and inhibition mechanisms.
• Medicinal Chemistry: Utilized for structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead compounds.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.
• Process Chemistry & Scale-Up: Acts as a key intermediate during the process development and optimization phase before commercial-scale API manufacturing.

Basic Information

Product Name	5-Pyrimidinecarboxamide,4-(2-Fluorophenyl)-1,2,3,4-Tetrahydro-6-Methyl-2-Oxo-(9Ci)
CAS No.	347318-96-1
Molecular Formula	C12H12FN3O2
Molecular Weight	249.24 g/mol
Synonyms	4-(2-Fluorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxo-5-pyrimidinecarboxamide; 4-(2-Fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxamide; 5-Pyrimidinecarboxamide, 4-(2-fluorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxo-; 347318-96-1; 4-(2-Fluorophenyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide
EINECS	Contact for details

Quality Control

Our 5-Pyrimidinecarboxamide,4-(2-Fluorophenyl)-1,2,3,4-Tetrahydro-6-Methyl-2-Oxo-(9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D and development. Certificates of Analysis (COA) with complete batch traceability are provided and can be tailored to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if necessary to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.