Description

Ethyl 4-Methyl-2-(Methylthio)-6-Oxo-1,6-Dihydropyrimidine-5-Carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the dihydropyrimidine class of heterocyclic compounds. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting cardiovascular and neurological pathways. It is essential for research institutions, CROs, and manufacturers engaged in the development and scale-up of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of dihydropyrimidine-based Active Pharmaceutical Ingredients (APIs).
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Contract Manufacturing: Used by CDMOs for the commercial-scale production of specialty drugs under cGMP conditions.
• Chemical Synthesis: Employed in multi-step organic synthesis to construct complex heterocyclic systems with potential biological activity.
• Reference Standard: Utilized as an analytical standard for quality control and method validation in pharmaceutical laboratories.

Basic Information

Product Name	Ethyl 4-Methyl-2-(Methylthio)-6-Oxo-1,6-Dihydropyrimidine-5-Carboxylate
CAS No.	344361-90-6
Molecular Formula	C9H12N2O3S
Molecular Weight	228.27 g/mol
Synonyms	5-Carbethoxy-4-methyl-2-methylmercapto-6-oxo-1,6-dihydropyrimidine; Ethyl 4-methyl-2-(methylsulfanyl)-6-oxo-1,6-dihydro-5-pyrimidinecarboxylate; 5-Ethoxycarbonyl-4-methyl-2-methylthio-6-oxo-1,6-dihydropyrimidine; 2-(Methylthio)-4-methyl-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid ethyl ester; CAS 344361-90-6
EINECS	Contact for details

Quality Control

Our Ethyl 4-Methyl-2-(Methylthio)-6-Oxo-1,6-Dihydropyrimidine-5-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects with material suitable for research use through to cGMP-grade production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.