Description

Fmoc-Orn(Mtt)-Oh is a specialized, orthogonally protected amino acid derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound is critical for enabling the precise, sequential assembly of complex peptides, particularly those requiring selective deprotection strategies. It is an essential building block for researchers and manufacturers in pharmaceutical development, biotechnology, and academic research, facilitating the creation of novel therapeutic peptides and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/tBu strategy, allowing for the controlled incorporation of ornithine.
• Synthesis of Branched and Cyclic Peptides: The orthogonal Mtt (4-methyltrityl) side-chain protection enables selective deprotection for subsequent modification or cyclization.
• Preparation of Peptide Conjugates: Used in creating peptide-drug conjugates, peptide-fluorophore labels, and other bioconjugates where specific side-chain functionalization is required.
• Research & Development of Novel Therapeutics: Essential for developing antimicrobial peptides (AMPs), hormone analogs, and other bioactive peptide sequences in drug discovery pipelines.
• Combinatorial Chemistry Libraries: Serves as a valuable component in generating diverse peptide libraries for high-throughput screening.

Basic Information

Product Name	Fmoc-Orn(Mtt)-Oh
CAS No.	343770-23-0
Molecular Formula	C41H39NO5
Molecular Weight	625.76 g/mol
Synonyms	Fmoc-Orn(Mtt)-OH; N-α-Fmoc-N-δ-(4-methyltrityl)-L-ornithine; Fmoc-L-ornithine(Mtt)-OH; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-((4-methylphenyl)diphenylmethyl)amino)pentanoic acid; Fmoc-Orn(4-Mtt)-OH; Nδ-(4-Methyltrityl)-Nα-Fmoc-L-ornithine; Fmoc-Ornithine(Mtt)-OH; Fmoc-Orn(Mtt)
EINECS	Contact for details

Quality Control

Our Fmoc-Orn(Mtt)-Oh is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and specific impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This material is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	-10.0° to -14.0° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.