Description

Sugammadex Sodium is a modified γ-cyclodextrin derivative specifically engineered as a selective relaxant binding agent. This compound is of critical importance in modern anesthesiology for the rapid and complete reversal of neuromuscular blockade induced by rocuronium or vecuronium. It is an essential pharmaceutical active ingredient for manufacturers developing injectable formulations used in hospital and surgical settings to enhance patient safety and procedural efficiency.

Application

• Pharmaceutical Active Pharmaceutical Ingredient (API): Primary use in the manufacture of sterile injectable solutions for the reversal of neuromuscular blockade.
• Hospital & Surgical Anesthesia: Key component in emergency and elective surgery protocols to facilitate rapid recovery of spontaneous breathing.
• Research & Development: Used in pharmacological studies related to neuromuscular transmission, drug-receptor interactions, and the development of new anesthetic adjuvants.
• Generic Drug Formulation: Serves as the core API for companies producing generic versions of sugammadex-based reversal agents.
• Critical Care Medicine: Potential application in ICU settings for managing residual paralysis post-surgery.

Basic Information

Product Name	Sugammadex Sodium
CAS No.	343306-79-6
Molecular Formula	C72H104Na8O48S8
Molecular Weight	2177.62 g/mol
Synonyms	Org 25969; Bridion (Brand Name); Sodium sugammadex; γ-Cyclodextrin derivative, sugammadex; (Per-6-(2-carboxyethylthio)-per-6-deoxy-γ-cyclodextrin) octasodium salt; Selective Relaxant Binding Agent (SRBA); 6-Per-(2-carboxyethylthio)-6-per-deoxy-γ-cyclodextrin octasodium salt
EINECS	Contact for details

Quality Control

Our Sugammadex Sodium is manufactured under strict quality systems suitable for pharmaceutical applications. It undergoes rigorous analytical testing to ensure identity, purity, and potency, aligning with ICH guidelines. A comprehensive Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and microbiological attributes is provided with each batch to support your regulatory filings and quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 10.0 %
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Bacterial Endotoxins	< 0.5 EU/mg
Microbial Enumeration	Complies with Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.