Description

Sugammadex CAS NO 343306-71-8 is a modified γ-cyclodextrin specifically engineered as a selective relaxant binding agent. This compound is critically important in modern anesthesiology for its ability to rapidly and effectively reverse neuromuscular blockade induced by rocuronium or vecuronium. It is an essential pharmaceutical active ingredient for manufacturers developing injectable hospital drugs, meeting the needs of surgical and intensive care settings where precise control of muscle relaxation is paramount.

Application

• Primary Pharmaceutical Ingredient: Used in the formulation of injectable solutions for the reversal of neuromuscular blockade.
• Hospital & Surgical Use: Critical in operating rooms and post-anesthesia care units (PACU) for rapid recovery from muscle relaxation.
• Anesthesia Reversal Agent: Specifically binds and encapsulates aminosteroid non-depolarizing neuromuscular blocking agents (NMBAs), facilitating their removal from the neuromuscular junction.
• Research & Development: Serves as a key reference standard and intermediate in pharmacological research for new anesthetic and reversal protocols.
• Generic Drug Manufacturing: A vital component for pharmaceutical companies producing generic versions of neuromuscular reversal drugs.
• Emergency Medicine: Provides a safety mechanism for the rapid reversal of deep blockade in cases of anaphylaxis or difficult airway management.

Basic Information

Product Name	Sugammadex
CAS No.	343306-71-8
Molecular Formula	C72H104Na8O48S8
Molecular Weight	2178.0 g/mol (as sodium salt)
Synonyms	Org 25969; Bridion® (Brand Name); (Per-6-(2-carboxyethylthio)-per-deoxy-γ-cyclodextrin, octasodium salt); γ-Cyclodextrin, per-6-(2-carboxyethylthio)-per-deoxy-, octasodium salt; Sugammadex Sodium; Selective Relaxant Binding Agent (SRBA); Modified γ-Cyclodextrin
EINECS	Contact for details

Quality Control

Our Sugammadex is manufactured under strict quality systems suitable for pharmaceutical applications. Each batch is tested to ensure it meets high-purity standards, with specifications aligned with pharmacopeial requirements. Comprehensive testing includes identity, assay, impurity profiling, and residual solvent analysis. A Certificate of Analysis (COA) documenting all test results is provided with every shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccant use within the primary container.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	≤10.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤20 ppm
Bacterial Endotoxins	<0.5 EU/mg
Microbial Enumeration	Complies with Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.