Description

Hepcidin-20 (Human) CAS NO 342790-23-2 is a bioactive peptide fragment of the human hepcidin hormone, a key regulator of systemic iron homeostasis. This high-purity synthetic peptide is essential for research into iron metabolism disorders, anemia of chronic disease, and novel therapeutic pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic developers focused on endocrinology and hematology.

Application

• Biomedical Research: Used as a reference standard and active agent in studies of iron regulation, inflammation, and hepcidin's role in disease.
• Drug Discovery & Development: Serves as a critical tool for screening, validating, and developing novel therapeutics targeting the hepcidin pathway for conditions like hemochromatosis and anemia.
• Diagnostic Assay Development: Employed as a calibrant and control in the development of immunoassays (ELISA) to measure hepcidin levels in clinical samples.
• Cell Culture & In Vitro Studies: Applied in cell-based assays to investigate the biological effects of hepcidin-20 on ferroportin internalization and cellular iron export.
• Structure-Activity Relationship (SAR) Studies: Used to map functional domains of the full-length hepcidin hormone and design peptide mimetics.

Basic Information

Product Name	Hepcidin-20 (Human)
CAS No.	342790-23-2
Molecular Formula	C97H152N34O27S8
Molecular Weight	2395.9 g/mol
Synonyms	Hepcidin-20; Hepcidin (20-47) (human); Liver-expressed antimicrobial peptide 1 (20-47); LEAP-1 (20-47); HAMP (20-47); Iron regulatory hormone peptide fragment; Hepc20; Hepcidin-25 fragment
EINECS	Contact for details

Quality Control

Our Hepcidin-20 (Human) is manufactured under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content. We adhere to GMP-grade principles for peptide synthesis and purification, ensuring reliability for critical preclinical studies.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider aliquoting to minimize freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Consistent with reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.