Description

(D-Phe5,Cys6,11,n-Me-D-Trp8)-Somatostatin-14 (5-12) Amide CAS NO 340821-13-8 is a synthetic, biologically active cyclic peptide analog of somatostatin. This compound is engineered for enhanced metabolic stability and receptor selectivity, making it a critical research tool and a potential precursor for therapeutic development. It is primarily utilized by pharmaceutical researchers, biotechnology companies, and academic institutions focused on endocrinology, oncology, and neurobiology.

Application

• Biomedical Research: Used as a selective ligand to study somatostatin receptor (SSTR) subtypes, particularly SSTR2 and SSTR5, in signal transduction pathways.
• Drug Discovery & Development: Serves as a key intermediate or reference standard in the development of novel peptide-based therapeutics for neuroendocrine tumors and acromegaly.
• In Vitro & In Vivo Studies: Employed in pharmacological assays and animal models to investigate the inhibition of growth hormone, insulin, and glucagon secretion.
• Diagnostic Agent Development: Acts as a backbone for developing radiolabeled (e.g., with 68Ga, 177Lu) compounds for targeted imaging and therapy (theranostics).
• Peptide Chemistry & Conjugation: Utilized in structural-activity relationship (SAR) studies and for creating peptide-drug conjugates due to its stable, constrained cyclic structure.

Basic Information

Product Name	(D-Phe5,Cys6,11,n-Me-D-Trp8)-Somatostatin-14 (5-12) Amide
CAS No.	340821-13-8
Molecular Formula	C54H68N14O10S2
Molecular Weight	1113.33 g/mol
Synonyms	D-Phe-Cys-Tyr-D-Trp-Lys-Cys-Thr-NH2 (cyclic 6-11 disulfide); BIM-23056; DC-23-116; Somatostatin (5-12) octapeptide analog; Cyclo[D-Phe-Cys-Tyr-D-Trp-Lys-Cys-Thr-NH2]; [D-Phe5, Cys6,11, N-Me-D-Trp8]-Somatostatin-14 (5-12) amide; Somatostatin Octapeptide Analog; SSTR2/5 Selective Agonist
EINECS	Contact for details

Quality Control

Our peptide products are manufactured under strict quality systems. Each batch of (D-Phe5,Cys6,11,n-Me-D-Trp8)-Somatostatin-14 (5-12) Amide undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing purity, peptide content, and solvent residues are provided to ensure compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Analysis	Within ±10% of theoretical
Water Content (KF)	≤ 8.0%
Acetate Content (HPLC)	≤ 15.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.