Description

Ac-Leu-Pro-Phe-Phe-Asp-Nh2 CAS NO 339990-02-2 is a synthetic hexapeptide amide derivative, featuring an N-terminal acetyl group and a C-terminal amide. This compound is of significant interest in biochemical and pharmaceutical research, particularly as a potential substrate or inhibitor for proteolytic enzymes like renin or other aspartic proteases. Its specific sequence makes it a valuable tool for studying enzyme kinetics, substrate specificity, and for the development of novel therapeutic agents. Researchers in medicinal chemistry, peptide synthesis, and drug discovery are the primary users of this specialized biochemical.

Application

• Biochemical Research: Used as a specific substrate or inhibitor in enzymatic assays to study the activity and mechanism of aspartic proteases, including renin.
• Medicinal Chemistry: Serves as a key intermediate or lead compound in the design and development of novel peptide-based pharmaceuticals targeting hypertension and related cardiovascular diseases.
• Protease Specificity Studies: Employed to investigate the substrate recognition and cleavage preferences of various proteolytic enzymes.
• Pharmaceutical Reference Standard: Utilized as a high-purity analytical standard for quality control and method development in peptide drug manufacturing.
• Peptide Library Synthesis: Acts as a building block or a template in the construction of combinatorial peptide libraries for high-throughput screening.
• Academic Research: Fundamental tool in university and institutional labs for teaching and advanced research in enzymology and peptide science.

Basic Information

Product Name	Ac-Leu-Pro-Phe-Phe-Asp-Nh2
CAS No.	339990-02-2
Molecular Formula	C41H56N8O9
Molecular Weight	804.95 g/mol
Synonyms	Acetyl-Leucyl-Prolyl-Phenylalanyl-Phenylalanyl-Aspartic Acid Amide; Ac-L-P-F-F-D-NH2; N-Acetyl-L-leucyl-L-prolyl-L-phenylalanyl-L-phenylalanyl-L-aspartamide; Hexapeptide Amide Ac-Leu-Pro-Phe-Phe-Asp-NH2; Renin Substrate Analog; Aspartic Protease Inhibitor Peptide; (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-4-methylpentanoyl]pyrrolidin-2-yl]formamido]-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-carbamoylbutanoic acid
EINECS	Contact for details

Quality Control

Our Ac-Leu-Pro-Phe-Phe-Asp-Nh2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available for every lot upon request. We are committed to providing materials that support reproducible and reliable scientific outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated at the recommended temperature.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.