Description

1-(2-Chloro-3-Pyridinyl)-5-[3-(Dimethylamino)Acryloyl]-3-Methyl-2,4(1H,3H)-Pyrimidinedione is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily sought by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of new chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of proprietary drug candidates, especially in oncology and central nervous system (CNS) research.
• Agrochemical Research: Serves as a structural motif in the development of new-generation pesticides and herbicides, leveraging its pyridine and pyrimidinedione core.
• Chemical Biology & Proteomics: Used as a specialized scaffold or linker in the design of chemical probes for target identification and validation studies.
• Academic & Industrial R&D: Employed in methodological chemistry research for studying novel heterocyclic reactions and building complex molecular libraries.
• Custom Synthesis: Basis for the contract manufacturing of bespoke organic compounds for clients in the life sciences sector.

Basic Information

Product Name	1-(2-Chloro-3-Pyridinyl)-5-[3-(Dimethylamino)Acryloyl]-3-Methyl-2,4(1H,3H)-Pyrimidinedione
CAS No.	339279-37-7
Molecular Formula	C15H15ClN4O3
Molecular Weight	334.76 g/mol
Synonyms	5-[3-(Dimethylamino)acryloyl]-1-(2-chloro-3-pyridinyl)-3-methyl-1H-pyrimidine-2,4-dione; 1-(2-Chloro-3-pyridinyl)-5-[3-(dimethylamino)-1-oxo-2-propen-1-yl]-3-methyl-2,4(1H,3H)-pyrimidinedione; 339279-37-7; 5-(3-(Dimethylamino)acryloyl)-1-(2-chloro-3-pyridyl)-3-methylpyrimidine-2,4(1H,3H)-dione
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development and commercial projects requiring compliance with cGMP and ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.