Description

Ethyl 2-((5-[3-(Trifluoromethyl)Phenyl]-2-Pyrimidinyl)Sulfanyl)Propanoate is a specialized organic intermediate featuring a pyrimidine core linked to a trifluoromethylphenyl group via a thioether-propanoate ester bridge. This compound matters for its role as a critical building block in the synthesis of advanced molecules, particularly in the pharmaceutical and agrochemical sectors, where the trifluoromethyl group is prized for its ability to modulate lipophilicity and metabolic stability. It is needed by research institutions and industrial manufacturers developing novel active ingredients, including kinase inhibitors, herbicides, and other fine chemicals requiring this specific molecular architecture.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates, especially those targeting kinase pathways for oncology and inflammatory diseases.
• Agrochemical Research: Used in the development of next-generation herbicides and fungicides, leveraging the bioactivity of the pyrimidine and trifluoromethyl motifs.
• Chemical Synthesis Building Block: Serves as a versatile synthon for constructing complex heterocyclic compounds in medicinal and process chemistry.
• Material Science Research: Potential use in the development of specialty polymers or organic electronic materials due to its conjugated system.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations engaged in custom synthesis and scale-up projects for client-specific molecules.

Basic Information

Product Name	Ethyl 2-((5-[3-(Trifluoromethyl)Phenyl]-2-Pyrimidinyl)Sulfanyl)Propanoate
CAS No.	339101-35-8
Molecular Formula	C₁₆H₁₅F₃N₂O₂S
Molecular Weight	356.36 g/mol
Synonyms	Ethyl 2-({5-[3-(trifluoromethyl)phenyl]pyrimidin-2-yl}sulfanyl)propanoate; 2-((5-(3-(Trifluoromethyl)phenyl)pyrimidin-2-yl)thio)propanoic acid ethyl ester; Propanoic acid, 2-[[5-[3-(trifluoromethyl)phenyl]-2-pyrimidinyl]thio]-, ethyl ester; CAS 339101-35-8
EINECS	Contact for details

Quality Control

Our Ethyl 2-((5-[3-(Trifluoromethyl)Phenyl]-2-Pyrimidinyl)Sulfanyl)Propanoate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are provided with every shipment. We support development and commercial projects with consistent quality, traceability, and documentation compliant with cGMP and ISO standards where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). This material is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Keep away from heat, sparks, and open flame. For long-term storage, consider storage under an inert gas such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.