Description

4-[3,4-Dihydro-2(1H)-Isoquinolinyl]-6-[(4-Fluorophenyl)Sulfanyl]-2-Pyrimidinamine is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure, designed for critical synthesis pathways. This compound matters for its role as a key building block in the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily needed by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders or other specialized therapeutic areas.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Biology Probe Development: Employed in the creation of molecular probes to study biological pathways and protein interactions due to its unique structural features.
• Process Chemistry & Scale-Up: Integral for developing and optimizing scalable synthetic routes for potential Active Pharmaceutical Ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development services for the global pharmaceutical industry.

Basic Information

Product Name	4-[3,4-Dihydro-2(1H)-Isoquinolinyl]-6-[(4-Fluorophenyl)Sulfanyl]-2-Pyrimidinamine
CAS No.	339017-67-3
Molecular Formula	C19H17FN4S
Molecular Weight	352.43 g/mol
Synonyms	6-[(4-Fluorophenyl)thio]-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidin-2-amine; 4-(3,4-Dihydro-1H-isoquinolin-2-yl)-6-[(4-fluorophenyl)sulfanyl]pyrimidin-2-amine; 2-Pyrimidinamine, 4-(1,2,3,4-tetrahydro-2-isoquinolinyl)-6-[(4-fluorophenyl)thio]-; 4-(1,2,3,4-Tetrahydroisoquinolin-2-yl)-6-(4-fluorophenylthio)pyrimidin-2-amine; CAS 339017-67-3
EINECS	Contact for details

Quality Control

Our 4-[3,4-Dihydro-2(1H)-Isoquinolinyl]-6-[(4-Fluorophenyl)Sulfanyl]-2-Pyrimidinamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere when not in use to prevent degradation and maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.