Description

tert-Butyl 4-((4-(4-Bromo-2-Fluorophenylamino)-6-Methoxyquinazolin-7-Yloxy)Methyl)Piperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of targeted therapeutic agents. This compound is critical for research and development in medicinal chemistry, particularly in the creation of kinase inhibitors. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of novel oncology and anti-inflammatory drugs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of small molecule kinase inhibitors for targeted cancer therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Preclinical Development: Serves as a critical precursor for producing active pharmaceutical ingredients (APIs) in early-stage development.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP-scale production of investigational new drugs.
• Biochemical Research: Used as a tool compound to study specific biological pathways and enzyme inhibition mechanisms.

Basic Information

Product Name	tert-Butyl 4-((4-(4-Bromo-2-Fluorophenylamino)-6-Methoxyquinazolin-7-Yloxy)Methyl)Piperidine-1-Carboxylate
CAS No.	338992-20-4
Molecular Formula	C26H30BrFN4O4
Molecular Weight	561.45 g/mol
Synonyms	1-Boc-4-((4-((4-Bromo-2-fluorophenyl)amino)-6-methoxyquinazolin-7-yl)oxy)methyl)piperidine; tert-Butyl 4-[[[4-[(4-Bromo-2-fluorophenyl)amino]-6-methoxy-7-quinazolinyl]oxy]methyl]-1-piperidinecarboxylate; BOC-Piperidine Quinazoline Derivative; 338992-20-4; 4-((4-(4-Bromo-2-fluorophenylamino)-6-methoxyquinazolin-7-yloxy)methyl)piperidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-((4-(4-Bromo-2-Fluorophenylamino)-6-Methoxyquinazolin-7-Yloxy)Methyl)Piperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment and handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.