Description

4-([(4-Chlorophenyl)Sulfonyl]Methyl)-6-[(4-Fluorobenzyl)Oxy]-2-Methylpyrimidine CAS NO 338960-43-3 is a high-purity, advanced pharmaceutical intermediate characterized by its distinct pyrimidine core functionalized with chlorophenylsulfonyl and fluorobenzyloxy groups. This compound matters for its critical role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. Pharmaceutical R&D teams and fine chemical manufacturers need this precise intermediate to develop next-generation drugs, leveraging its structural complexity for creating compounds with potential biological activity.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of novel drug candidates, especially in oncology and central nervous system (CNS) therapeutic research.
• Active Pharmaceutical Ingredient (API) Development: Used as a core structural motif for developing new APIs targeting specific enzymes or receptors.
• Biochemical Research: Employed in academic and industrial laboratories as a standard or probe molecule for studying structure-activity relationships (SAR).
• Agrochemical Synthesis: Functions as an intermediate in the development of advanced pesticides or herbicides, utilizing its heterocyclic structure.
• Material Science Chemistry: Acts as a specialty monomer or additive in the synthesis of advanced polymers or functional materials.
• Contract Manufacturing & Custom Synthesis: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke chemical production and scale-up projects.

Basic Information

Product Name	4-([(4-Chlorophenyl)Sulfonyl]Methyl)-6-[(4-Fluorobenzyl)Oxy]-2-Methylpyrimidine
CAS No.	338960-43-3
Molecular Formula	C19H16ClFN2O3S
Molecular Weight	406.86 g/mol
Synonyms	4-[(4-Chlorophenyl)sulfonylmethyl]-6-[(4-fluorobenzyl)oxy]-2-methylpyrimidine; 6-[(4-Fluorobenzyl)oxy]-4-[(4-chlorophenyl)sulfonylmethyl]-2-methylpyrimidine; 2-Methyl-4-((4-chlorophenyl)sulfonyl)methyl-6-(4-fluorobenzyloxy)pyrimidine; 338960-43-3; 4-((4-Chlorophenyl)sulfonylmethyl)-6-(4-fluorobenzyloxy)-2-methylpyrimidine; 4-[(4-Chlorobenzene-1-sulfonyl)methyl]-6-[(4-fluorophenyl)methoxy]-2-methylpyrimidine
EINECS	Contact for details

Quality Control

Our 4-([(4-Chlorophenyl)Sulfonyl]Methyl)-6-[(4-Fluorobenzyl)Oxy]-2-Methylpyrimidine is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing all specified parameters. Our quality commitment aligns with cGMP standards where applicable, ensuring reliability for critical pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.