Description

tert-Butyl 4-Hydroxy-2-Methyl-5H,6H,7H,8H-Pyrido[3,4-D]Pyrimidine-7-Carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the pyridopyrimidine class of heterocyclic compounds. This compound is a critical building block in modern medicinal chemistry, valued for its role in constructing complex molecular architectures. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for therapeutic areas requiring sophisticated small-molecule synthesis.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Organic Synthesis Building Block: Employed in multi-step synthesis to introduce the pyrido[3,4-d]pyrimidine core into more complex molecules.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for cGMP production of clinical trial materials and commercial APIs.
• Academic Research: Utilized in university and institutional labs for studying heterocyclic chemistry and developing new synthetic methodologies.

Basic Information

Item	Details
Product Name	tert-Butyl 4-Hydroxy-2-Methyl-5H,6H,7H,8H-Pyrido[3,4-D]Pyrimidine-7-Carboxylate
CAS No.	338739-89-2
Molecular Formula	C13H19N3O3
Molecular Weight	265.31 g/mol
Synonyms	7-(tert-Butoxycarbonyl)-4-hydroxy-2-methyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine; tert-Butyl 4-hydroxy-2-methyl-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylate; 4-Hydroxy-2-methyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-7-carboxylic acid tert-butyl ester; 338739-89-2; Pyrido[3,4-d]pyrimidine-7-carboxylic acid, 5,6,7,8-tetrahydro-4-hydroxy-2-methyl-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Hydroxy-2-Methyl-5H,6H,7H,8H-Pyrido[3,4-D]Pyrimidine-7-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and cGMP applications. Certificates of Analysis (COA) with complete traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.