Description

tert-Butyl 4-Hydroxy-2-(Methylthio)-5,8-Dihydropyrido[3,4-D]Pyrimidine-7(6H)-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex fused pyridopyrimidine structure. This compound matters as a critical building block in the synthesis of novel, targeted therapeutic agents, offering researchers a reliable and well-defined starting material. It is primarily needed by pharmaceutical R&D departments and fine chemical manufacturers engaged in developing kinase inhibitors and other small molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potent kinase inhibitors for oncology and inflammatory disease research.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization programs.
• Biochemical Tool Compound: Used in the development of assay probes to study specific enzyme pathways and cellular signaling mechanisms.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for exploratory synthetic chemistry and drug discovery projects.

Basic Information

Product Name	tert-Butyl 4-Hydroxy-2-(Methylthio)-5,8-Dihydropyrido[3,4-D]Pyrimidine-7(6H)-Carboxylate
CAS No.	338739-81-4
Molecular Formula	C14H19N3O3S
Molecular Weight	309.38 g/mol
Synonyms	7-(tert-Butoxycarbonyl)-4-hydroxy-2-(methylthio)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine; tert-Butyl 4-hydroxy-2-(methylsulfanyl)-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylate; 338739-81-4; 4-Hydroxy-2-(methylthio)-5,8-dihydropyrido[3,4-d]pyrimidine-7(6H)-carboxylic acid tert-butyl ester; Pyrido[3,4-d]pyrimidine-7(6H)-carboxylic acid, 5,8-dihydro-4-hydroxy-2-(methylthio)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Hydroxy-2-(Methylthio)-5,8-Dihydropyrido[3,4-D]Pyrimidine-7(6H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical development. Comprehensive Certificates of Analysis (COA) documenting all critical quality attributes are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.