Description

n-(4-([3-Chloro-4-(2-Pyrimidinyloxy)Anilino]Sulfonyl)Phenyl)Acetamide is a high-purity, advanced pharmaceutical intermediate with a complex sulfonamide-aniline-pyrimidine structure. This compound is critical for the synthesis of targeted therapeutic agents, offering a precise molecular scaffold for drug discovery and development. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of novel small-molecule drugs, particularly in oncology and other specialized therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially kinase inhibitors.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization in academic and industrial R&D labs.
• Oncology Drug Development: A crucial precursor in the manufacturing pathways for investigational anti-cancer compounds targeting specific cellular pathways.
• Biochemical Research: Employed as a reference standard or a probe compound in biochemical assays to study enzyme inhibition and cellular signaling mechanisms.
• Custom Synthesis: Provided as a starting material for contract research and manufacturing organizations (CROs/CMOs) specializing in complex organic molecules.

Basic Information

Product Name	n-(4-([3-Chloro-4-(2-Pyrimidinyloxy)Anilino]Sulfonyl)Phenyl)Acetamide
CAS No.	338413-30-2
Molecular Formula	C18H15ClN4O4S
Molecular Weight	418.85 g/mol
Synonyms	N-[4-[[3-Chloro-4-(pyrimidin-2-yloxy)phenyl]sulfamoyl]phenyl]acetamide; 2-[[3-Chloro-4-[[4-(acetylamino)phenyl]sulfonyl]amino]phenoxy]pyrimidine; 338413-30-2; Acetamide, N-[4-[[[3-chloro-4-(2-pyrimidinyloxy)phenyl]amino]sulfonyl]phenyl]-; UNII-6Y7P5N82B8; 6Y7P5N82B8; BDBM50111235; AKOS025310647; A-841720.
EINECS	Contact for details

Quality Control

Our n-(4-([3-Chloro-4-(2-Pyrimidinyloxy)Anilino]Sulfonyl)Phenyl)Acetamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to ensure stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Single Maximum Impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.