Description

2-Hydroxy-3-Trifluoromethyl-Benzaldehyde is a versatile trifluoromethylated aromatic aldehyde derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, combining a phenolic hydroxyl group with a trifluoromethyl substituent, enables precise modulation of electronic and steric properties in target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) agents, anti-inflammatory compounds, and enzyme inhibitors where the trifluoromethyl group is a critical pharmacophore.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides, where the introduction of fluorine atoms improves lipophilicity, membrane permeability, and environmental stability.
• Ligand & Catalyst Development: Serves as a starting material for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs), leveraging the aldehyde and hydroxyl groups for complexation.
• Material Science Research: Employed in the synthesis of advanced polymers, liquid crystals, and organic electronic materials, where the trifluoromethyl group influences dielectric constant and thermal stability.
• Fluorine Chemistry Research: A valuable substrate for studying nucleophilic aromatic substitution and other reactions specific to fluorinated aromatic systems in academic and industrial R&D settings.

Basic Information

Product Name	2-Hydroxy-3-Trifluoromethyl-Benzaldehyde
CAS No.	336628-67-2
Molecular Formula	C8H5F3O2
Molecular Weight	190.12 g/mol
Synonyms	3-Trifluoromethylsalicylaldehyde; 2-Hydroxy-3-(trifluoromethyl)benzaldehyde; 3-(Trifluoromethyl)-2-hydroxybenzaldehyde; Salicylaldehyde, 3-trifluoromethyl-; 2-Hydroxy-α,α,α-trifluoro-m-tolualdehyde; 3-Trifluoromethyl-2-hydroxybenzaldehyde; m-Trifluoromethylsalicylaldehyde; Benzaldehyde, 2-hydroxy-3-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-3-Trifluoromethyl-Benzaldehyde is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications and relevant industry standards for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong oxidizing agents, strong bases, and sources of heat.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.