Description

L-β-Homothreonine Hydrochloride is a high-purity, non-proteinogenic amino acid derivative used as a critical chiral building block in advanced organic synthesis. Its value lies in providing a specific stereochemical configuration and functional group arrangement essential for constructing complex bioactive molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in peptide-based drug discovery.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate a modified threonine analogue, influencing peptide structure and bioactivity.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies and as a standard in analytical method development for amino acid analysis.
• Prodrug Design: Utilized in the design of prodrugs where the homothreonine moiety can be cleaved enzymatically to release the active drug molecule.
• Ligand and Catalyst Development: Acts as a precursor for chiral ligands used in asymmetric catalysis or in the synthesis of metal-organic frameworks (MOFs).

Basic Information

Product Name	L-β-Homothreonine Hydrochloride
CAS No.	336182-14-0
Molecular Formula	C5H12ClNO3
Molecular Weight	169.61 g/mol
Synonyms	(2S,3S)-2-Amino-3-hydroxyhexanoic acid hydrochloride; L-β-Homothreonine HCl; (2S,3S)-3-Hydroxy-2-aminohexanoic acid hydrochloride; β-Homothreonine hydrochloride; Hthr(β)-OH·HCl; L-β-Homo-Thr-OH·HCl; 3-Hydroxy-L-norleucine hydrochloride (related); Non-proteinogenic amino acid derivative
EINECS	Contact for details

Quality Control

Our L-β-Homothreonine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing specific results for identity, purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.