Description

(D-Arg6,Azagly10)-GnRH II (Human, Chicken) is a synthetic peptide analog of Gonadotropin-Releasing Hormone II, a key neurohormone involved in the regulation of reproductive functions. This modified sequence, featuring D-arginine at position 6 and an aza-glycine at position 10, is designed for enhanced stability and specific receptor binding affinity in research applications. It serves as a critical tool for scientists and pharmaceutical developers in endocrinology, neurobiology, and drug discovery programs targeting reproductive disorders.

Application

• Endocrine and Reproductive Research: Fundamental studies on the mechanism of action of GnRH II and its role in the hypothalamic-pituitary-gonadal axis.
• Drug Discovery & Development: Used as a reference standard or lead compound in the development of novel therapeutics for fertility control, hormone-dependent cancers, and endocrine diseases.
• Biochemical Assay Development: Serves as a key reagent in the development and validation of receptor binding assays, enzyme-linked immunosorbent assays (ELISAs), and other in vitro diagnostic tests.
• Neuroscience Studies: Investigation of the neuromodulatory functions of GnRH II beyond reproduction, including potential roles in behavior and cognition.
• Veterinary Research: Applied in studies of reproductive physiology and management in avian and mammalian species, leveraging its cross-reactivity.

Basic Information

Product Name	(D-Arg6,Azagly10)-GnRH II (Human, Chicken)
CAS No.	335380-72-8
Molecular Formula	C₆₀H₈₈N₂₀O₁₃
Molecular Weight	1297.5 g/mol
Synonyms	(D-Arg6,Azagly10)-GnRH II; [D-Arg6, AzaGly10]-GnRH II; Chicken GnRH II Analog; LHRH II Analog; Gonadotropin-Releasing Hormone II (5-10) analog; pGlu-His-Trp-Ser-His-D-Arg-Trp-AzaGly-Pro-Gly-NH₂; Azaglycine10-GnRH II; [AzaGly10]-cGnRH-II
EINECS	Contact for details

Quality Control

Every batch of (D-Arg6,Azagly10)-GnRH II (Human, Chicken) is manufactured and analyzed under strict quality management protocols. We guarantee high purity and batch-to-batch consistency through comprehensive analytical techniques including HPLC, MS, and amino acid analysis. A Certificate of Analysis (COA) detailing purity, identity, and related substances is provided with each shipment to ensure it meets the exacting standards required for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, keep under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 8.0%
Peptide Content	≥ 80.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.